Abstract Tumor microenvironment (TME) is the internal environment in which tumor cells survive, consisting of tumor cells, fibroblasts, endothelial cells, and immune cells, as well as non-cellular components, such as exosomes and cytokines.Exosomes are tiny extracellular vesicles (40-160nm) containing active substances, such as proteins, lipids Ostivone and nucleic acids.Exosomes carry biologically active miRNAs to shuttle between tumor cells and TME, thereby affecting tumor development.
Tumor-derived exosomal miRNAs induce matrix reprogramming in TME, creating a microenvironment that is conducive to tumor Football - Protective - Girdles growth, metastasis, immune escape and chemotherapy resistance.In this review, we updated the role of exosomal miRNAs in the process of TME reshaping.